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Search and compare Sikeston, MO hotels and accomomodations using our interactive hotel finder. Book the Best Sikeston Hotels on Tripadvisor: Find 2,208 traveller reviews, 528 candid photos, and prices for hotels in Sikeston, Missouri, United States. Sikeston Tourism; Sikeston Hotels; Sikeston Bed and Breakfast; Sikeston Vacation Packages; Flights to Sikeston; Sikeston Restaurants; Things to Do in Sikeston It is 35 miles south of Cape Girardeau and 140 miles north of Memphis, Tennessee. Free WiFi access is available throughout the property. America’s Best Value Inn & Suites in Sikeston, Missouri, is located off Exit 67 on Interstate 55, and Sikeston city center is 3.1 mi away. Best Sikeston Hotels on Tripadvisor: Find 2,198 traveller reviews, 496 candid photos, and prices for hotels in Sikeston, Missouri, United States. 120 S Interstate Dr. Sikeston, … The hotels and motels in Sikeston are downtown and near I-55, Exit 67. Looking for Sikeston Hotel? 2-star hotels from $55. 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